The FUSE client can download the BLAST databases listed in available BLAST databases. The client is configured to download the most recent version of these BLAST databases at the time of the first search, but these BLAST databases will not be automatically updated as newer databases become available.

The FUSE client downloads the BLAST database over the network, so the first BLAST search against a new database will be slow. The client caches the database on disk and subsequent searches will be faster. Or, terminate the existing instance and start a new one. The new instance will cache the latest data.